Potential antitumour agents. 11. 9-anilinoacridines

Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions.

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Dimeric analogues of non-cationic tricyclic aromatic carboxamides are a new class of cytotoxic agents.

Anti-cancer drug design·1999

5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.

Journal of medicinal chemistry·1999

Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

Journal of medicinal chemistry·1999

Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity.

Journal of medicinal chemistry·1999

N-Substituted 2-(2,6-dinitrophenylamino)propanamides: novel prodrugs that release a primary amine via nitroreduction and intramolecular cyclization.

Journal of medicinal chemistry·1999

Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.

Journal of medicinal chemistry·2026

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.

Journal of medicinal chemistry·2026

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Journal of medicinal chemistry·2026

Discovery and Optimization of a WRN Helicase Inhibitor Series through Structure-Guided Drug Design from a Covalent Fragment Binding Insight.

Journal of medicinal chemistry·2026

Recent Advances in Antiviral Medicinal Chemistry against Flaviviruses Driven by Multistrategic Approaches.

Journal of medicinal chemistry·2026

A Combined Chemoinformatics- and Machine Learning-Based Approach Identifies Chlormidazole as a Drug Repurposing Candidate against Aggressive Prostate Cancer.

Journal of medicinal chemistry·2026

Targeting host lipogenesis with a diarylamide inhibitor disrupts SARS-CoV-2 replication.

iScience·2026

Modular synthesis of α-tertiary amino acids from C-H feedstocks.

Chemical science·2026

Negative allosteric modulation of NMDA receptors with GluN2B subunit: synthesis of γ-amino alcohols embedded in a 1-benzoxepine scaffold.

RSC medicinal chemistry·2026

Synthesis of photoactive compounds from 2H-pyran-2-ones and their photophysical properties.

RSC advances·2026

DABPU-DE targeting host adipose triglyceride lipase provides broad-spectrum anti-coronavirus effects in vitro.

Frontiers in pharmacology·2026

Inhibition and Molecular Recognition of Lactoperoxidase by Acetohydrazide-Based Sulfonamide Derivatives.

Journal of molecular recognition : JMR·2026

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Potential antitumour agents. 11. 9-anilinoacridines

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Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions.

Dimeric analogues of non-cationic tricyclic aromatic carboxamides are a new class of cytotoxic agents.

5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.

Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

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Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.

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Modular synthesis of α-tertiary amino acids from C-H feedstocks.

Negative allosteric modulation of NMDA receptors with GluN2B subunit: synthesis of γ-amino alcohols embedded in a 1-benzoxepine scaffold.

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Potential antitumour agents. 11. 9-anilinoacridines

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