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Summary
Drug fever is a rare side effect of isoniazid treatment. This case highlights how isoniazid can cause persistent fever, which resolves upon stopping the medication and reappears when restarted.
Area of Science:
- Pharmacology
- Infectious Diseases
Background:
- Isoniazid is a primary treatment for tuberculosis.
- Drug fever is an uncommon adverse reaction to isoniazid therapy.
Observation:
- A patient with tuberculous peritonitis presented with persistent, spiking fever while on isoniazid.
- The fever resolved after isoniazid discontinuation.
Findings:
- Rechallenging the patient with isoniazid confirmed it as the cause of the fever.
- This demonstrates an uncommon adverse reaction to isoniazid.
Implications:
- Highlights the importance of considering drug fever in patients on isoniazid presenting with unexplained fever.
- Emphasizes careful monitoring for adverse reactions during tuberculosis treatment.