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[Gentamicin-susceptibility of various pathogens isolated from clinical materials]
Abstract:
We studied on the antibacterial activity of gentamicin against various pathogens isolated from clinical materials mainly isolated during 1974 and 1975, comparing with other antibiotics. Beta hemolytic streptococci, pneumococci and enterococci are less susceptible to gentamicin than staphylococci. Staph, aureus and Staph. epidermidis resistant to various antibiotics are very susceptible to gentamicin, and no resistant strain to this drug was found. Haemophilus influenzae, H. parainfluenzae and H. parahaemolyticus are very susceptible to gentamicin, and there is no resistant strain to this drug. Escherichia coli, Klebsiella, Citrobacter, Serratia and five species of Proteus are more susceptible to gentamicin and tobramycin than dibekacin and amikacin. A few resistant or less susceptible strains to gentamicin are found in E. coli, Citrobacerr, Serratia, Pr. morganii and Pr. rettgeri. Pr. inconstans is less susceptible to gentamicin than other species of Proteus. Antibacterial activity of gentamicin against Pseudomonas aeruginosa is very strong, but dibekacin and tobramycin are stronger. Gentamicin-resistant strains of Pseudomonas aeruginosa are now rather few.
Insights
Gentamicin shows strong antibacterial activity against many pathogens, including antibiotic-resistant Staphylococcus strains. While generally effective, some resistance was noted in specific Gram-negative bacteria like E. coli and Pseudomonas aeruginosa.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Antibiotic resistance is a growing concern in clinical settings.
- Gentamicin is a widely used aminoglycoside antibiotic for bacterial infections.
Purpose of the Study:
- To evaluate the in vitro antibacterial activity of gentamicin against various clinical pathogens.
- To compare gentamicin's efficacy with other antibiotics, including dibekacin, amikacin, and tobramycin.
- To identify potential gentamicin-resistant strains.
Main Methods:
- Antibacterial susceptibility testing of gentamicin against clinical isolates.
- Comparative analysis of gentamicin with other antibiotics.
Main Results:
- Gentamicin demonstrated high efficacy against Staphylococcus aureus and Staphylococcus epidermidis, including multi-drug resistant strains.
- Haemophilus species (H. influenzae, H. parainfluenzae, H. parahaemolyticus) were highly susceptible to gentamicin, with no resistant strains identified.
- Escherichia coli, Klebsiella, Citrobacter, Serratia, and Proteus species showed susceptibility, though some resistance was observed in E. coli, Citrobacter, Serratia, Pr. morganii, and Pr. rettgeri.
- Gentamicin exhibited strong activity against Pseudomonas aeruginosa, though dibekacin and tobramycin were more potent. Few gentamicin-resistant Pseudomonas aeruginosa strains were found.
Conclusions:
- Gentamicin remains a valuable antibiotic, particularly against Gram-positive cocci like staphylococci.
- Monitoring for emerging resistance in Gram-negative bacteria is crucial.
- Comparative studies highlight the nuanced efficacy of different aminoglycosides against specific pathogens.