Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Anencephaly with incomplete twinning (diprosopus).

V M Riccardi, C A Bergmann

|October 1, 1977

Summary

This case study presents diprosopus with anencephaly, suggesting a shared developmental pathway. The findings support a common pathogenetic mechanism for neural tube defects and monozygotic twinning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.

Molecular neurodegeneration·2019

Same author

Café au lait spots: the pediatrician's perspective.

Pediatrics in review·2001

Same author

The vasculopathy of NF1 and histogenesis control genes.

Clinical genetics·2001

Same author

Neoplasms in neurofibromatosis 1 are related to gender but not to family history of cancer.

Genetic epidemiology·2000

Same author

Associations of clinical features in neurofibromatosis 1 (NF1).

Genetic epidemiology·2000

Same author

Of mass and men: neurofibromas and histogenesis.

Archives of dermatology·2000

Area of Science:

Developmental biology
Teratology
Human genetics

Background:

Neural tube defects (NTDs) are common congenital abnormalities.
Monzygotic twinning involves the incomplete separation of a single fertilized egg.
The etiology of both NTDs and twinning is not fully understood.

Purpose of the Study:

To present a rare case of diprosopus (facial duplication) with anencephaly (absence of the brain and spinal cord).
To explore the potential pathogenetic link between NTDs and monozygotic twinning.

Main Methods:

Case report presentation.
Review of relevant literature on diprosopus, anencephaly, and twinning.

Main Results:

A fetus presented with both diprosopus and anencephaly.
This concurrence suggests a potential shared underlying developmental mechanism.

Conclusions:

The co-occurrence of diprosopus and anencephaly supports the hypothesis of a common pathogenetic pathway.
This finding may provide insights into the developmental processes underlying both NTDs and monozygotic twinning.

Related Experiment Videos