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Effect of propranolol on glucose tolerance in hyperthyroidism
Postgraduate Medical Journal
|November 1, 1977
Summary
Propranolol treatment in hyperthyroid patients can affect glucose tolerance. While most maintained normal glucose levels, one patient experienced abnormal glucose tolerance and lost diurnal variation, highlighting a potential risk.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Hyperthyroidism is associated with altered glucose metabolism.
- Beta-blockers like propranolol are used to manage hyperthyroid symptoms.
Purpose of the Study:
- To investigate the effect of propranolol on glucose tolerance in hyperthyroid patients.
- To assess changes in diurnal glucose rhythm during propranolol treatment.
Main Methods:
- Glucose tolerance tests were conducted on six hyperthyroid patients.
- Tests were performed in the morning and afternoon, before and after 2 weeks of propranolol treatment.
Main Results:
- All patients initially had normal glucose tolerance and diurnal rhythm.
- Five patients maintained normal glucose tolerance during treatment.
- One patient developed abnormal glucose tolerance and abolished diurnal variation.
Conclusions:
- Propranolol may impair glucose tolerance in some hyperthyroid individuals.
- The potential for propranolol to worsen glucose metabolism in hyperthyroidism should be considered.