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The effect of histocompatibility-2 type on response to friend leukemia virus in mice
Abstract:
Two types of quantitative response to the F-B strain of Friend virus in segregating generations of a cross involving a susceptible (DBA/2 or BALB/c; H-2(2)) and a resistant (C57BL/6; H-2(b)) mouse strain show a marked correlation with the H-2 type of the mice. Essential susceptibility, as determined by the splenomegalic response to high virus doses, is controlled by a single pair of alleles which segregates independently with respect to the H-2 locus. However, relative susceptibility, as determined by the incidence of the splenomegalic response at moderate or low levels of virus dosage, is significantly greater among mice homozygous or heterozygous for the H-2(d) allele than among H-2(b) homozygotes in these populations. In addition, the incidence of recovery from splenomegaly induced by a given level of virus dosage is significantly greater in H-2(b) homozygotes than in segregants of other H-2 types among their littermates. Possible mechanisms responsible for these effects are discussed.
Insights
The H-2 type in mice significantly influences their response to Friend virus infection. Mice with H-2(d) alleles show greater susceptibility and slower recovery, while H-2(b) homozygotes exhibit resistance.
Area of Science:
- Immunogenetics
- Virology
- Mouse Models
Background:
- Friend virus (FV) infection in mice is a model for studying viral pathogenesis and host immune responses.
- Genetic factors, particularly those linked to the Major Histocompatibility Complex (MHC), play a crucial role in determining FV susceptibility and disease progression.
Purpose of the Study:
- To investigate the correlation between the H-2 haplotype and quantitative responses to Friend virus infection in mice.
- To elucidate the genetic control of susceptibility and recovery from FV-induced splenomegaly.
Main Methods:
- Cross-breeding of susceptible (H-2(d)) and resistant (H-2(b)) mouse strains.
- Quantitative assessment of splenomegaly as a measure of response to varying Friend virus doses.
- Analysis of H-2 haplotype segregation and its association with disease incidence and recovery.
Main Results:
- Essential susceptibility to high Friend virus doses is controlled by an H-2 independent locus.
- Relative susceptibility to moderate/low virus doses is significantly higher in mice with H-2(d) alleles (homozygous or heterozygous) compared to H-2(b) homozygotes.
- H-2(b) homozygous mice demonstrate a significantly higher incidence of recovery from splenomegaly.
Conclusions:
- The H-2 haplotype significantly influences both susceptibility and recovery from Friend virus infection in mice.
- H-2(d) alleles are associated with increased susceptibility and impaired recovery, while H-2(b) alleles confer resistance and promote recovery.
- These findings highlight the critical role of MHC in antiviral immunity and disease outcome.