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Experimental observations on the integration of bladder and urethral function.

E J McGuire

    Investigative Urology
    |January 1, 1978
    PubMed
    Summary

    Pelvic nerve stimulation relaxes urethral smooth and skeletal muscles, indicating components of urethral resistance. This study reveals a spinal reflex involving reciprocal inhibition of the detrusor-external sphincter in cats.

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    Area of Science:

    • Urology
    • Neuroscience
    • Physiology

    Background:

    • The bladder and urethra's function involves complex neural control.
    • Understanding urethral resistance mechanisms is crucial for managing lower urinary tract disorders.

    Purpose of the Study:

    • To investigate bladder and urethral pressure responses to pelvic sympathetic and pudendal nerve stimulation in anesthetized cats.
    • To elucidate the neural control mechanisms underlying urethral resistance and detrusor-external sphincter interactions.

    Main Methods:

    • Stimulation of pelvic sympathetic and pudendal nerves in 60 anesthetized cats.
    • Measurement of bladder and urethral pressure responses.
    • Pharmacological blockade with propranolol to assess receptor involvement.

    Main Results:

    • Urethral resistance comprises both smooth and skeletal muscle components, which relax upon pelvic nerve stimulation.
    • Reciprocal inhibition of the detrusor-external sphincter is a spinal-mediated reflex triggered by pelvic or pudendal nerve stimulation.
    • Propranolol administration blocked the urethral smooth muscle pressure decrease during pelvic nerve stimulation, implicating beta-receptors.

    Conclusions:

    • Pelvic nerve stimulation induces relaxation of both urethral smooth and skeletal muscles.
    • A spinal reflex mediates reciprocal inhibition between the detrusor and external sphincter.
    • Beta-adrenergic receptors play a role in the smooth muscle relaxation of the urethra.

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