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Radial neuronal assemblies, ectopia and necrosis of developing cortex: a case analysis.

V S Caviness, P Evrard, G Lyon

    Acta Neuropathologica
    |January 19, 1978
    PubMed
    Summary
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    Midcortical laminar necrosis in an infant brain suggests damage occurred in the third trimester. Surviving neurons show radial displacement, indicating the molecular layer acts as a barrier to migration.

    Area of Science:

    • Neuroscience
    • Developmental Neuroscience
    • Pathology

    Background:

    • Examining neuropathology in a case of infant mortality.
    • Investigating the timing and mechanisms of cortical malformations.

    Observation:

    • A case study of an 18-month-old child revealed reduced cerebral convolutions and midcortical laminar necrosis.
    • Normal underlying laminar neuronal arrangement and gyral pattern suggest late gestation onset of damage.
    • Surviving neurons maintained radial organization, but some migrated outward, breaching the pia.

    Findings:

    • Cortical damage likely occurred in the third trimester of gestation.
    • The molecular layer appears to act as a barrier, preventing tangential and limiting radial neuron displacement.
    • Mesenchymal-glial scarring at breached pia sites led to neuronal ectopia in the subarachnoid space.

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    Implications:

    • This suggests radial glial fibers play a crucial role in cortical development and neuronal migration.
    • Understanding these mechanisms can inform research into neurodevelopmental disorders.
    • The findings highlight the importance of the molecular layer's integrity during fetal brain development.