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Studies in tissue glycogen in acute stress
Indian Journal of Physiology and Pharmacology
|January 1, 1978
Summary
Electro-shock impacts glycogen levels in cardiac, skeletal, and liver muscles. Cardiac and skeletal muscles show supercompensation, while liver glycogen remains depleted for up to 5 hours post-shock.
Area of Science:
- Biochemistry
- Physiology
- Neuroscience
Background:
- Electro-shock is a medical procedure with physiological effects.
- Glycogen serves as a primary energy reserve in various tissues.
- Understanding tissue-specific metabolic responses to stress is crucial.
Purpose of the Study:
- To investigate the dynamic changes in glycogen levels in liver, cardiac, and skeletal muscles following electro-shock.
- To determine the time course of glycogen supercompensation and depletion in different tissues.
Main Methods:
- Estimation of glycogen content in liver, cardiac, and skeletal muscle tissues.
- Analysis of glycogen levels at various time points during the recovery period after electro-shock.
Main Results:
- Supercompensation of glycogen observed in cardiac muscles at 1.5 hours and skeletal muscles at 5 hours post-electro-shock.
- Liver glycogen levels remained below control values for at least 5 hours after electro-shock.
- Minimum ventricular glycogen levels coincided with peak glycogen supercompensation in cardiac muscle at 1.5 hours.
- Glycogen levels in all three tissues returned to control levels within 24 hours post-electro-shock.
Conclusions:
- Electro-shock induces distinct and time-dependent alterations in tissue glycogen metabolism.
- Cardiac and skeletal muscles exhibit a capacity for glycogen supercompensation post-stress.
- The liver demonstrates a prolonged depletion of glycogen following electro-shock, suggesting differential metabolic vulnerability.