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Related Experiment Videos

Plasmalogenase is elevated in early demyelinating lesions.

L A Horrocks, S Spanner, R Mozzi

    Advances in Experimental Medicine and Biology
    |January 1, 1978
    PubMed
    Summary
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    Plasmalogenase activity increases during central nervous system demyelination, preceding cellular invasion. This enzyme may cause oligodendrocyte damage, leading to demyelination in conditions like distemper virus infection.

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Cell Biology

    Background:

    • Plasmalogenase hydrolyzes ethanolamine plasmalogens, with activity paralleling myelination during development.
    • The enzyme is concentrated in oligodendroglial cells, not myelin, and may be involved in lipid metabolism for white matter.
    • Plasmalogens are precursors for thromboxane and prostaglandin synthesis.

    Purpose of the Study:

    • To investigate the role and activity of plasmalogenase in demyelinating conditions of the central nervous system (CNS).
    • To determine if elevated plasmalogenase activity is an early indicator of demyelination.
    • To explore the potential involvement of plasmalogenase in oligodendrocyte damage.

    Main Methods:

    • Assaying plasmalogenase activity in CNS tissues, including those affected by distemper virus, anti-myelin antibodies, and ischemia.

    Related Experiment Videos

  • Comparing plasmalogenase activity with lysosomal enzyme activities (beta-glucuronidase, acid proteinase, neutral proteinase).
  • Evaluating phospholipase activities acting on phosphatidyl ethanolamine.

    • Main Results:

    • Plasmalogenase activity was significantly elevated (4.9-fold) in early demyelinating lesions caused by distemper virus.
    • Elevated plasmalogenase activity preceded cellular invasion and lysosomal enzyme activation.
    • Other phospholipases acting on phosphatidyl ethanolamine were not activated and showed lower activity than plasmalogenase in control tissues.
    • Plasmalogenase activity also increased after anti-myelin antibody injection and ischemia.

    Conclusions:

    • Elevated plasmalogenase activity is an early event in CNS demyelination.
    • Plasmalogenase may contribute to oligodendrocyte necrosis, a key process in demyelination.
    • The enzyme's specificity for plasmalogens suggests a role in lipid metabolism disruption during demyelination.