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[Pseudomembranous colitis caused by antibiotics].

B Meyer, P Geering

    Schweizerische Medizinische Wochenschrift
    |November 11, 1978
    PubMed
    Summary
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    Antibiotic use, particularly clindamycin, can lead to severe pseudomembranous colitis. This case highlights the potential for fatal complications like pulmonary embolism from this antibiotic-induced condition.

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Pseudomembranous colitis is a serious gastrointestinal condition often linked to antibiotic administration.
    • Several antibiotics have been implicated, with clindamycin frequently reported in recent literature.

    Observation:

    • An 81-year-old male developed severe diarrhea one week after a 9-day course of clindamycin and a subsequent 9-day course of epicillin following colon cancer surgery.
    • The patient experienced progressively worsening diarrhea, leading to death from central pulmonary embolism ten days later.

    Findings:

    • Autopsy confirmed severe pseudomembranous colitis affecting the entire large intestine.
    • The exact cause of antibiotic-induced pseudomembranous colitis remains under investigation.

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  • Current hypotheses suggest alterations in the gut microbiota due to antibiotics, potentially involving toxin-producing Clostridia species.

    • Implications:

    • This case underscores the critical need for vigilance regarding antibiotic-induced pseudomembranous colitis, even after antibiotic cessation.
    • Early recognition and management of this condition are crucial to prevent severe outcomes.
    • Further research into the etiopathology is necessary to elucidate the mechanisms and develop targeted therapies.