Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth deficiency dysmorphic syndromes.

D W Smith

    Postgraduate Medical Journal
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Congenital hypoplasia, including skeletal and tissue malformations, often results in growth deficiencies without catch-up growth. Prognosis for height is linked to adult heights within specific genetic syndromes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cancer mortality at very old ages.

    Cancer·1996
    Same author

    Racial differences on psychological measures in combat veterans seeking treatment for PTSD.

    Journal of personality assessment·1996
    Same author

    Mosquito-borne viruses and epidemic polyarthritis.

    The Medical journal of Australia·1996
    Same author

    Consensus phylogeny of Dictyostelium.

    Experientia·1995
    Same author

    Role of ventrolateral medulla catecholamine cells in hypothalamic neuroendocrine cell responses to systemic hypoxia.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·1995
    Same author

    Venous catheter thrombus formation and pulmonary embolism in children.

    Pediatric pulmonology·1995
    Same journal

    Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials.

    Postgraduate medical journal·2026
    Same journal

    Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

    Postgraduate medical journal·2026
    Same journal

    Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

    Postgraduate medical journal·2026
    Same journal

    Care, cash, and proof: forensic accountability for war-related starvation.

    Postgraduate medical journal·2026
    Same journal

    Response to traumatic injuries in polo players in England.

    Postgraduate medical journal·2026
    Same journal

    Aids to venesection and parenteral drug administration in patients with difficult veins.

    Postgraduate medical journal·2026
    See all related articles

    Area of Science:

    • Medical Genetics
    • Developmental Biology
    • Pediatric Endocrinology

    Background:

    • Many malformations stem from congenital hypoplasia affecting skeletal or multiple tissues, seen in osteochondrodysplasias and dysmorphic syndromes.
    • Causes include teratogens, chromosomal abnormalities, gene mutations, and idiopathic syndromes, often correlating linear and brain growth deficits.
    • Postnatal growth typically lacks catch-up, with children growing at a normal rate relative to their diminished birth size.

    Purpose of the Study:

    • To elucidate the nature of congenital hypoplasia disorders.
    • To discuss the implications for growth and development.
    • To address diagnostic and prognostic considerations.

    Main Methods:

    • Review of established medical literature on congenital hypoplasia.

    Related Experiment Videos

  • Analysis of growth patterns and correlations within syndromes.
  • Examination of diagnostic challenges, such as bone age interpretation.

    • Main Results:

    • Congenital hypoplasia leads to significant linear growth deficiency and, often, brain growth deficiency.
    • Skeletal morphogenesis issues can render 'bone age' assessments unreliable for maturational age.
    • Lack of postnatal catch-up growth is a characteristic feature.

    Conclusions:

    • There is no current therapy for congenital hypoplasia disorders.
    • Prognosis for adult height can be estimated by considering adult heights within the specific disorder and parental genetic background.
    • Example: XO Turner syndrome girls show significant height reduction relative to parental height.