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Related Experiment Videos

Glucose lactate interrelations in sheep.

P E Reilly, L G Chandrasena

    The American Journal of Physiology
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    In trained sheep, glucose and lactate levels are interconnected. Glucose production from lactate depends on lactate availability, while lactate production from glucose depends on glucose concentration.

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    Area of Science:

    • Metabolic Physiology
    • Animal Science
    • Biochemistry

    Background:

    • Carbohydrate homeostasis is crucial for energy metabolism.
    • The interconversion between glucose and lactate plays a key role in this process.
    • Understanding these dynamics is vital in physiological and metabolic research.

    Purpose of the Study:

    • To investigate the interrelationships between glucose and lactate pools in trained sheep.
    • To determine how arterial concentrations of glucose and lactate influence their respective metabolic pathways.

    Main Methods:

    • Utilized the constant-infusion, isotope-dilution method.
    • Studied six trained sheep deprived of food overnight.
    • Measured arterial plasma concentrations and net entry/production rates of glucose and lactate.

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    Main Results:

    • Arterial lactate concentration correlated linearly with net lactate entry rate.
    • Net glucose production from lactate was dependent on lactate availability.
    • Arterial glucose concentration correlated with net glucose entry rate and lactate production from glucose.

    Conclusions:

    • Net glucose formation from lactate is contingent upon lactate availability.
    • Net lactate production from glucose is a function of arterial glucose concentration.
    • In healthy sheep, glucose-to-lactate and lactate-to-glucose conversion rates are primarily dictated by their respective arterial concentrations.