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Related Experiment Videos

Ovulation induction in amenorrheic women.

C M March, V Davajan, D R Mishell

    Obstetrics and Gynecology
    |January 1, 1979
    PubMed
    Summary

    Clomiphene citrate is effective for ovulation induction in amenorrheic patients with withdrawal bleeding. Human menopausal gonadotropins (hMG) or bromocriptine are alternatives based on galactorrhea presence and bleeding response.

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    Area of Science:

    • Reproductive Endocrinology
    • Infertility Treatment

    Background:

    • Amenorrhea affects women's fertility.
    • Ovulation induction is crucial for conception in amenorrheic patients.

    Purpose of the Study:

    • To determine the optimal drug for ovulation induction in amenorrheic patients.
    • To evaluate the efficacy of clomiphene citrate, bromocriptine, and hMG.

    Main Methods:

    • Seventy-six patients with amenorrhea were treated with clomiphene citrate, bromocriptine, and/or hMG.
    • Patients were assessed for ovulation and conception.
    • Withdrawal bleeding after progesterone and presence of galactorrhea were noted.

    Main Results:

    • Clomiphene citrate induced ovulation in 55% of patients.
    • Patients with withdrawal bleeding had higher ovulation rates (73%) with clomiphene citrate.
    • hMG-hCG led to ovulation and conception in all patients who failed clomiphene.
    • Bromocriptine was effective in patients with amenorrhea-galactorrhea.

    Conclusions:

    • Treatment choice for ovulation induction depends on progesterone withdrawal bleeding and galactorrhea.
    • Clomiphene citrate is the first-line treatment for patients with withdrawal bleeding.
    • hMG or bromocriptine are recommended for patients unresponsive to clomiphene, considering galactorrhea status.

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