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Related Experiment Video

Updated: Jun 19, 2026

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
09:35

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation

Published on: July 17, 2018

Sex pheromone in the dog.

M Goodwin, K M Gooding, F Regnier

    Science (New York, N.Y.)
    |February 9, 1979
    PubMed
    Summary

    Methyl p-hydroxybenzoate, a compound found in female dog vaginal secretions during estrus, triggers sexual arousal and mounting behavior in male dogs. This pheromone plays a key role in canine reproductive signaling.

    Area of Science:

    • Animal Behavior
    • Reproductive Biology
    • Canine Ethology

    Background:

    • Methyl p-hydroxybenzoate is present in vaginal secretions of female dogs during estrus.
    • Estrus is the period of sexual receptivity in female mammals.

    Purpose of the Study:

    • To investigate the role of methyl p-hydroxybenzoate in canine sexual behavior.
    • To determine if this compound acts as a pheromone in dogs.

    Main Methods:

    • Identifying methyl p-hydroxybenzoate in estrous female dog vaginal secretions.
    • Applying synthetic methyl p-hydroxybenzoate to the vulvas of anestrous or spayed female dogs.
    • Observing the sexual responses of male dogs when housed with treated females.

    Main Results:

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    • Male dogs exhibited sexual arousal and attempted to mount females treated with methyl p-hydroxybenzoate.
    • The compound appears to induce sexual behavior in males, regardless of the female's reproductive state.

    Conclusions:

    • Methyl p-hydroxybenzoate functions as a sex pheromone in dogs.
    • This chemical signal elicits specific sexual responses in male canines, influencing reproductive behavior.