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[Proliferative kinetics of antibody-forming cells normally and exposed to vinblastine]
The proliferative kinetics of IgM antibody-producing cells (APC) of mice immunized by sheep red blood cells was studied using autoradiography and vinblastine. The incorporation index for APC was determined every 4 hours from 72 to 112 hours of the immune response. The significance of recruitment in APC exponential growth was proven by means of 3 different regimes of 3H-thymidine introduction to immunized mice. The discontinuous character of recruitment and its resistance to vinblastine were shown. It is suggested that vinblastine impared both APC and their precursors.
The proliferative kinetics of IgM antibody-producing cells (APC) of mice immunized by sheep red blood cells was studied using autoradiography and vinblastine. The incorporation index for APC was determined every 4 hours from 72 to 112 hours of the immune response. The significance of recruitment in APC exponential growth was proven by means of 3 different regimes of 3H-thymidine introduction to immunized mice. The discontinuous character of recruitment and its resistance to vinblastine were shown. It is suggested that vinblastine impared both APC and their precursors.