Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain tryptophan in isolated aggressive mice.

B L Miller, J S Pachter, L Valzelli

    Neuropsychobiology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sexually dimorphic differences in angiogenesis markers predict brain aging trajectories.

    bioRxiv : the preprint server for biology·2023
    Same author

    Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.

    Alzheimer's & dementia : the journal of the Alzheimer's Association·2020
    Same author

    Dopamine receptor D<sub>4</sub> (DRD<sub>4</sub>) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

    NeuroImage. Clinical·2019
    Same author

    Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.

    Molecular psychiatry·2017
    Same author

    Application of quantitative DTI metrics in sporadic CJD.

    NeuroImage. Clinical·2014
    Same author

    Examining the value of lexical retrieval treatment in primary progressive aphasia: two positive cases.

    Brain and language·2013

    Social isolation in mice alters daily rhythms of brain tryptophan and increases food intake. Isolated mice show lower, sustained tryptophan levels, suggesting altered metabolism and dietary intake impacts.

    Area of Science:

    • Neuroscience
    • Behavioral Biology
    • Chronobiology

    Background:

    • Tryptophan, an essential amino acid, is a precursor to serotonin and melatonin.
    • Circadian rhythms regulate physiological processes, including feeding and neurotransmitter synthesis.
    • Social isolation is known to induce behavioral and physiological changes.

    Purpose of the Study:

    • To investigate the impact of social isolation on circadian variations in whole brain tryptophan levels.
    • To examine the relationship between social isolation, food intake, and brain tryptophan levels in mice.
    • To determine if social isolation disrupts diurnal rhythms of tryptophan and feeding behavior.

    Main Methods:

    • Male Albino-Swiss mice were housed in either grouped or isolated conditions.

    Related Experiment Videos

  • A 12:12 light-dark cycle (08:00–20:00) was maintained throughout the study.
  • Whole brain tryptophan levels and food intake were measured across a 24-hour period.

    • Main Results:

    • Grouped mice exhibited a significant diurnal rhythm in brain tryptophan levels.
    • Isolated mice displayed sustained, significantly lower brain tryptophan levels.
    • Both isolated and grouped mice showed synchronized daily rhythms in food intake, with isolated mice consuming more overall.

    Conclusions:

    • Social isolation in mice is associated with altered tryptophan metabolism and disrupted diurnal tryptophan rhythms.
    • Increased food consumption in isolated mice may be an attempt to compensate for altered tryptophan levels.
    • These findings highlight the intricate relationship between social environment, diet, and neurochemical regulation.