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Related Experiment Videos

Lymphocyte adherence in multiple sclerosis.

P Dore-Duffy, R B Zurier, J Donaldson

    Neurology
    |February 1, 1979
    PubMed
    Summary
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    Peripheral blood lymphocytes from multiple sclerosis patients show increased adherence to measles-infected cells. This lymphocyte adherence test may aid in diagnosing multiple sclerosis (MS) and monitoring disease activity.

    Area of Science:

    • Immunology
    • Neurology
    • Cell Biology

    Background:

    • Peripheral blood lymphocytes in multiple sclerosis (MS) patients exhibit unique adherence properties.
    • Previous reports suggest increased lymphocyte adherence to measles-infected cells in MS patients compared to controls.

    Purpose of the Study:

    • To confirm the observation of increased lymphocyte adherence in multiple sclerosis patients.
    • To investigate the correlation between lymphocyte adherence and the clinical status of multiple sclerosis.

    Main Methods:

    • Peripheral blood lymphocytes were isolated from multiple sclerosis patients and control groups.
    • Lymphocyte adherence to measles-infected human epithelial cells was quantified.
    • Adherence values were correlated with clinical diagnosis certainty and disease activity.

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    Main Results:

    • Confirmed significantly greater adherence of lymphocytes from multiple sclerosis patients to measles-infected cells.
    • Lymphocyte adherence values correlated positively with the diagnostic certainty of multiple sclerosis.
    • Observed increases in lymphocyte adherence during clinical exacerbations in individual patients.

    Conclusions:

    • The adherence of peripheral blood lymphocytes to measles-infected cells is a validated finding in multiple sclerosis.
    • Lymphocyte adherence testing shows potential as a diagnostic aid for multiple sclerosis.
    • This test may also serve as a biomarker for monitoring multiple sclerosis disease activity and clinical exacerbations.