Histological investigation on the so-called urethral syndrome

The urethral syndrome is generally not associated clinically with urethral changes, however, histology often reveals inflammatory or degenerative alterations. The conventionally diagnosed urethral syndrome can certainly be considered to be a synonym of chronic urethritis in adult females. The remarkable histological lesions were rupture of elastic fibers in the submucosa and the vascular wall, and a decrease of acid mucopolysaccharides in each layer of the urethra, accompanied by lymphocytic infiltration.