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Evidence that cells from experimental tumours can activate coagulation factor X
British Journal of Cancer
|August 1, 1979
Summary
Certain tumor cells exhibit procoagulant activity by directly activating Coagulation Factor X. This suggests a novel cellular pathway for initiating blood clotting, separate from known mechanisms.
Area of Science:
- Biochemistry
- Oncology
- Hematology
Background:
- Tumor cells can exhibit procoagulant activity.
- The mechanisms of tumor-induced coagulation are not fully understood.
Purpose of the Study:
- To investigate the procoagulant activity of experimental tumor cells.
- To determine the specific coagulation factors involved in this activity.
Main Methods:
- Assessing the effect of tumor cells on plasma recalcification time.
- Measuring thrombin generation in plasma supplemented with specific coagulation factors.
Main Results:
- Cells from Lewis lung carcinoma, Ehrlich carcinoma ascites, and JW sarcoma ascites markedly shortened recalcification time in normal, Factor VIII-, and Factor VII-deficient plasma, but not in Factor X-deficient plasma.
- These tumor cells generated thrombin when provided with prothrombin and Factor X, independent of Factor VII.
- Cells from Sarcoma 180 ascites showed no procoagulant activity.
Conclusions:
- Certain experimental tumor cells directly activate Coagulation Factor X.
- This activation suggests a distinct cellular pathway for initiating blood clotting, separate from intrinsic and extrinsic pathways.