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Related Experiment Videos

Permanent tooth sizes in 46,XX-males.

L Alvesalo, A de la Chapelle

    Annals of Human Genetics
    |October 1, 1979
    PubMed
    Summary

    XX-males exhibit smaller permanent tooth sizes, comparable to females, indicating growth retardation of primary genetic origin due to Y-chromosome gene absence. This growth deficit begins early in development and persists through childhood.

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    Area of Science:

    • Genetics
    • Human Biology
    • Endocrinology

    Background:

    • XX-males, a genetic condition, present with male phenotypes despite lacking a Y chromosome.
    • Previous studies suggest potential growth abnormalities in individuals with sex chromosome aneuploidies.

    Purpose of the Study:

    • To investigate permanent tooth size in XX-males as an indicator of growth patterns.
    • To explore the genetic basis of growth retardation in XX-males.

    Main Methods:

    • Comparative analysis of permanent tooth dimensions in XX-males versus control groups (males and females).
    • Examination of tooth size relative to familial members (mothers and fathers).

    Main Results:

    • XX-males displayed significantly smaller permanent teeth than control males, similar to control females.
    • Tooth size in XX-males was smaller than their male relatives but comparable to their mothers.
    • Fathers of XX-males had tooth sizes similar to control males, and mothers similar to control females.

    Conclusions:

    • Growth retardation in XX-males is of primary genetic origin, linked to the absence of Y-chromosome genes.
    • The observed growth deficit is apparent early in development, persisting through childhood.
    • Genes influencing maleness (e.g., testis-determining genes) are likely distinct from those regulating overall growth in this condition.

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