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Inhibition of glycolysis in hearts during ischemic perfusion
Recent Advances in Studies on Cardiac Structure and Metabolism
|January 1, 1975
Abstract:
Rates of glycolysis were determined in the isolated perfused rat heart under aerobic, anoxic, and ischemic conditions. The rate was accelerated in anoxic and was inhibited in ischemic tissue. Glycolytic inhibition developed at the level of glyceraldehyde-3-P dehydrogenase and was associated with accumulation of high levels of tissue lactate and H+.