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Rubella vaccine trial in children

I B Hillary, P N Meenan, A H Griffith

    British Medical Journal
    |May 31, 1969
    PubMed

    Insights

    The RA 27/3 rubella vaccine effectively generated antibodies in children without significant side effects. Importantly, the vaccine did not spread to unvaccinated siblings in shared households.

    Area of Science:

    • Immunology
    • Virology
    • Pediatrics

    Background:

    • Rubella virus infection poses risks, especially to non-immune individuals.
    • Vaccination is crucial for preventing rubella transmission and associated complications.

    Purpose of the Study:

    • To evaluate the immunogenicity and safety of the RA 27/3 attenuated rubella virus vaccine (Plotkin strain).
    • To assess the potential for vaccine-induced rubella virus transmission within households.

    Main Methods:

    • Administering the RA 27/3 rubella vaccine to 21 non-immune children.
    • Monitoring for clinical reactions post-vaccination.
    • Conducting serological examinations on vaccinated children and their siblings (53 non-immune, 29 immune).

    Main Results:

    • All 21 vaccinated children demonstrated a significant antibody response.
    • No appreciable or marked clinical reactions were observed in the vaccinated group.
    • No evidence of rubella virus infection transmission was detected among siblings.

    Conclusions:

    • The RA 27/3 rubella vaccine is immunogenic and well-tolerated in non-immune children.
    • Household transmission of the rubella vaccine strain is unlikely.

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