Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug accumulation and dose finding (authors' transl)].

H Kurz

    Arzneimittel-Forschung
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Drug accumulation occurs when intake exceeds elimination. Dosing intervals and half-life determine drug concentration, guiding physicians in patient-specific dosage calculations for improved therapeutic outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Editorial.

    Wiener medizinische Wochenschrift (1946)·2022
    Same author

    [PIMS-a new pediatric challenge].

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde·2021
    Same author

    Long-Term Respiratory Support for Children and Adolescents in Austria: A National Survey.

    Klinische Padiatrie·2015
    Same author

    Experimental verification of carrier multiplication in graphene.

    Nano letters·2014
    Same author

    The burden of pneumococcal meningitis in Austrian children between 2001 and 2008.

    European journal of pediatrics·2014
    Same author

    [IT systems in radiology and IT systems for radiologists].

    Der Radiologe·2013

    Area of Science:

    • Pharmacokinetics
    • Drug Metabolism
    • Clinical Pharmacology

    Context:

    • Drug accumulation is a fundamental pharmacokinetic principle.
    • Understanding drug elimination is crucial for safe and effective medication use.
    • Repeated dosing necessitates careful consideration of drug accumulation dynamics.

    Purpose:

    • To explain the pharmacokinetic principles of drug accumulation.
    • To demonstrate how dosing parameters influence drug concentration.
    • To provide a framework for calculating initial and maintenance drug doses.

    Summary:

    • Drug accumulation is predictable based on the balance between drug input and elimination rates.
    • Key parameters like dosing interval and biological half-life allow calculation of accumulation rates and steady-state concentrations.

    Related Experiment Videos

  • Initial and maintenance doses can be determined using these pharmacokinetic principles.

    • Impact:

    • Provides physicians with a scientific basis for individualizing patient drug dosages.
    • Helps optimize therapeutic drug monitoring and minimize adverse drug events.
    • Enhances the understanding of drug behavior in the body during repeated administration.