Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioavailability of acetazolamide tablets.

G J Yakatan, E L Frome, R G Leonard

    Journal of Pharmaceutical Sciences
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk of brainstem necrosis in pediatric patients with central nervous system malignancies after pencil beam scanning proton therapy.

    Acta oncologica (Stockholm, Sweden)·2019
    Same author

    Some Results for the Normal Manova Linear Functional Relationships Model.

    Biometrical journal. Biometrische Zeitschrift·2019
    Same author

    Enhanced antiglioma activity of chimeric HCMV/HSV-1 oncolytic viruses.

    Gene therapy·2007
    Same author

    Bronchoscopic closure of bronchopleural fistula using gelfoam.

    The Journal of the Association of Physicians of India·2005
    Same author

    Influence of concomitant quinidine administration on dextromethorphan disposition in rats.

    Journal of veterinary pharmacology and therapeutics·2004
    Same author

    Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial.

    Journal of the American Academy of Dermatology·2001
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Bioequivalence of acetazolamide tablets was assessed. While most bioavailability parameters were similar, two lots showed higher peak plasma concentrations, indicating lot-to-lot bioinequivalence.

    Area of Science:

    • Pharmacokinetics
    • Pharmaceutical Sciences
    • Drug Bioavailability

    Background:

    • Acetazolamide is a carbonic anhydrase inhibitor with therapeutic applications.
    • Ensuring consistent drug product quality is crucial for patient safety and efficacy.
    • Variability in drug manufacturing can lead to differences in bioavailability.

    Purpose of the Study:

    • To evaluate the lot-to-lot bioequivalence of acetazolamide tablets from a single manufacturer.
    • To assess key pharmacokinetic parameters including AUC, Tmax, and Cmax.
    • To explore the correlation between in vitro tests and in vivo bioavailability.

    Main Methods:

    • A single oral dose of 250 mg acetazolamide was administered to 20 healthy volunteers.
    • Five different lots of acetazolamide tablets were tested using a balanced incomplete block design.

    Related Experiment Videos

  • Plasma acetazolamide levels were quantified using an enzymatic assay.
  • Bioavailability parameters were calculated using digital computer fitting of plasma concentration-time data.

    • Main Results:

    • No significant differences were found in the area under the curve (AUC) or time to peak plasma concentration (Tmax) among the tested acetazolamide tablet lots.
    • Two of the five tested lots exhibited statistically significant higher peak plasma concentrations (Cmax) compared to the other three lots.
    • Lot-to-lot bioinequivalence was confirmed for acetazolamide tablets based on Cmax.

    Conclusions:

    • Significant lot-to-lot bioinequivalence exists among acetazolamide tablets from the same manufacturer, primarily due to differences in peak plasma concentrations.
    • In vitro tests showed some correlation with in vivo data but require further refinement for accurate prediction of bioinequivalence.
    • Manufacturing processes need careful control to ensure consistent acetazolamide tablet quality and therapeutic performance.