[Histopathological diagnosis in the animal experiment (author's transl)]

Spontaneous and experimentally induced organ alterations in laboratory animals do not always coincide with comparable lesions in human pathology. In addition, the discrimination between experimental tissue alterations and non-pathological structural variations may be difficult. In such cases a clear-cut separation can only be achieved by a proven dose-response relation, which, however, requires a quantitative or semiquantitative registration of histological findings.