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Azidocillin levels in tracheobronchial secretions
Scandinavian Journal of Respiratory Diseases
|October 1, 1979
Summary
Azidocillin concentrations in serum and respiratory secretions were measured in patients. No clear correlation was found between drug levels in the blood and lung secretions.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Infectious Diseases
Background:
- Antibiotics are crucial for treating respiratory infections.
- Understanding drug penetration into respiratory secretions is vital for effective treatment.
- Azidocillin is a penicillin antibiotic used for bacterial infections.
Purpose of the Study:
- To measure azidocillin concentrations in patient serum and tracheobronchial secretions.
- To investigate the relationship between serum and secretion levels of azidocillin.
- To explore potential correlations with tracheobronchitis.
Main Methods:
- 20 patients received an oral dose of 0.75 g azidocillin.
- Serum concentrations were monitored for 4 hours.
- Tracheobronchial secretion samples were collected via fiberoptic bronchoscopy 1-2 hours post-administration.
Main Results:
- Azidocillin concentrations in tracheobronchial secretions ranged from undetectable to 1.1 µg/ml.
- No significant correlation was observed between serum and secretion drug levels.
- A trend towards higher secretion levels was noted in patients with signs of tracheobronchitis.
Conclusions:
- Azidocillin exhibits variable penetration into tracheobronchial secretions.
- Serum drug levels do not reliably predict concentrations in respiratory secretions.
- Further research may clarify the clinical significance of azidocillin levels in tracheobronchitis.