Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Precancerous changes in the stomach.

T Kawachi, M Kurisu, N Numanyu

    Cancer Research
    |July 1, 1976
    PubMed
    Summary

    Intestinal metaplasia, a precancerous state linked to gastric cancer, was studied in over 130 human stomach specimens. Two types were identified, with potential for a third, showing distinct enzyme and cell marker profiles.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Burst intensification by singularity emitting radiation in multi-stream flows.

    Scientific reports·2017
    Same author

    Coherent X-ray beam metrology using 2D high-resolution Fresnel-diffraction analysis.

    Journal of synchrotron radiation·2016
    Same author

    Comparative study of treatment for distal radius fractures with two different palmar locking plates.

    The Journal of hand surgery, European volume·2016
    Same author

    Nonlinear increase of X-ray intensities from thin foils irradiated with a 200 TW femtosecond laser.

    Scientific reports·2015
    Same author

    Ability of 18-fludeoxyglucose positron emission tomography/CT to detect incidental cancer.

    The British journal of radiology·2014
    Same author

    Room temperature ferromagnetism with large magnetic moment at low field in rare-earth-doped BiFeO₃ thin films.

    Journal of physics. Condensed matter : an Institute of Physics journal·2013

    Area of Science:

    • Gastroenterology
    • Oncology
    • Histopathology

    Background:

    • Intestinal metaplasia is frequently observed in human gastric carcinoma.
    • Intestinalization represents abnormal differentiation and is considered a precancerous condition.
    • Understanding intestinal metaplasia is crucial for gastric cancer research.

    Purpose of the Study:

    • To investigate intestinal metaplasia in human gastric carcinoma specimens.
    • To classify types of intestinal metaplasia based on disaccharidase activity and cell presence.
    • To explore potential differences in sucrase activity and blood group reactivity between metaplasia types.

    Main Methods:

    • Development of a Tes-Tape method for visualizing disaccharidases.
    • Histochemical techniques for sucrase activity.
    • Analysis of over 130 surgically removed human stomach specimens.
    • Classification of intestinal metaplasia into types I and II based on enzyme and cell markers.

    Main Results:

    • Type I intestinal metaplasia showed sucrase, maltase, trehalase, alkaline phosphatase, goblet cells, and Paneth cells.
    • Type II intestinal metaplasia exhibited sucrase and maltase, but lacked alkaline phosphatase and trehalase; goblet cells were present, but Paneth cells were absent.
    • A novel histochemical technique revealed some villi with goblet cells lacked sucrase staining, suggesting a possible third type of metaplasia.
    • Sucrases from Type I showed blood group reactivity, while Type II sucrases did not.

    Conclusions:

    • Intestinal metaplasia in gastric carcinoma can be classified into at least two distinct types based on enzymatic and cellular markers.
    • Differences in sucrase activity and blood group reactivity may distinguish these types.
    • Further research is warranted to confirm the existence of a third type of intestinal metaplasia and its clinical significance.

    Related Experiment Videos