Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgens.

R V Brooks

    Clinics in Endocrinology and Metabolism
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Testosterone, produced by Leydig cells, circulates freely to target cells. Anti-androgens block this uptake, impacting testosterone

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids.

    Biopolymers·2017
    Same author

    Detection of cortisol administration in the horse.

    Equine veterinary journal·1999
    Same author

    Possible indices for the detection of the administration of dihydrotestosterone to athletes.

    The Journal of steroid biochemistry and molecular biology·1992
    Same author

    Human chorionic gonadotrophin and sport.

    British journal of sports medicine·1991
    Same author

    Criteria to indicate testosterone administration.

    British journal of sports medicine·1990
    Same author

    A radioimmunoassay for the metabolites of the anabolic steroid nandrolone.

    Journal of pharmaceutical and biomedical analysis·1988
    Same journal

    Long-term complications of diabetes.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic retinopathy: current concepts of evaluation and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Diabetic neuropathies and pain.

    Clinics in endocrinology and metabolism·1986
    Same journal

    The diabetic foot: pathophysiology and treatment.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Autonomic neuropathy: its diagnosis and prognosis.

    Clinics in endocrinology and metabolism·1986
    Same journal

    Dialysis: continuous ambulatory peritoneal dialysis and haemodialysis.

    Clinics in endocrinology and metabolism·1986
    See all related articles

    Area of Science:

    • Endocrinology
    • Molecular Biology

    Background:

    • Testosterone synthesis primarily occurs in Leydig cells.
    • Testosterone secretion exhibits episodic patterns and circadian variation.
    • Only unbound testosterone in circulation is biologically active.

    Purpose of the Study:

    • To elucidate the mechanism of testosterone uptake by target cells.
    • To understand the action of anti-androgens in relation to testosterone.

    Main Methods:

    • Review of existing literature on testosterone metabolism and action.
    • Analysis of cellular uptake mechanisms for testosterone and its metabolites.

    Main Results:

    • Free testosterone enters target cells and binds to specific receptors.
    • In some tissues, testosterone is converted to 5alpha-dihydrotestosterone before receptor binding.
    • Anti-androgens primarily inhibit the uptake of testosterone or its metabolites.

    Conclusions:

    • Testosterone's biological activity depends on its free fraction and cellular uptake.
    • The mechanism of action for anti-androgens involves blocking testosterone uptake pathways.