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Related Experiment Videos

Male intersexuality presenting at puberty.

P Dowd, J Dewhurst, J Ginsburg

    British Journal of Obstetrics and Gynaecology
    |November 1, 1977
    PubMed
    Summary

    A 15-year-old with a 46XY karyotype presented with virilization symptoms. The case highlights partial anatomical testicular failure despite male testosterone levels.

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    Area of Science:

    • Endocrinology
    • Genetics
    • Pediatric Endocrinology

    Background:

    • A 15-year-old female presented with signs of virilization, including a deep voice, male-patterned hair growth, and clitoromegaly.
    • The patient exhibited primary amenorrhea, indicating a disruption in typical female pubertal development.

    Observation:

    • Karyotype analysis revealed a 46XY chromosomal complement.
    • Physical examination showed a 4 cm phallic clitoris with a posterior urethral orifice.

    Findings:

    • Surgical intervention included gonadectomy and clitoridectomy.
    • Histological examination suggested partial anatomical testicular failure, indicating an imperfect attempt at masculinization.

    Implications:

    • This case underscores the complexity of disorders of sex development (DSDs) in adolescents.
    • Understanding the spectrum of intersex conditions is crucial for accurate diagnosis and management.

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