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[Analysis of the inhibitory influence of whole human erythrocytes on plasma heparin activity]
The accelerating effect of intact human erythrocytes upon the thrombin time of plasma (deprothrombinized, thrombocyte depleted) was independent of the presence of calcium ions, preincubation, erythrocytes and plasma, and was not accompanied by a decrease of the free heparin level in the plasma. Acceleration of the process of plasma fibrinogen transformation into fibrin caused by the whole erythrocytes was not conditioned by the endogenous heparin inhibition, but reflected the cell fibrinoplastic activity. The results obtained are against the idea advanced in literature on the regulating influence of the whole erythrocytes upon the endogenous heparin level in the blood.
The accelerating effect of intact human erythrocytes upon the thrombin time of plasma (deprothrombinized, thrombocyte depleted) was independent of the presence of calcium ions, preincubation, erythrocytes and plasma, and was not accompanied by a decrease of the free heparin level in the plasma. Acceleration of the process of plasma fibrinogen transformation into fibrin caused by the whole erythrocytes was not conditioned by the endogenous heparin inhibition, but reflected the cell fibrinoplastic activity. The results obtained are against the idea advanced in literature on the regulating influence of the whole erythrocytes upon the endogenous heparin level in the blood.