[Development of febrile and leukocytic responses in diabetic rabbits with aseptic inflammation]

Diabetic rabbits displayed a statistically significant reduction of the pyretic index in comparison with control. There was some delay in the development of leukocytic reaction, although no difference in leukocytosis was observed in the diabetic and control rabbits. Leukopenia, most pronounced in control animals 18 to 20 hours after the beginning of observation, was absent in some of the rabbits with diabetes. There were seen no significant differences in the intensity of leukocytic infiltration of the inflammatory focus in the diabetic and control rabbits. A diminished pyretic reaction during aseptic inflammation in rabbits with diabetes was apparently associated with the reduced capacity of leukocytes of the inflammatory focus to release pyrogens, determining the fever.