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Compatibility of penicillin and ascorbic acid injection.

H J Pfeifer, J W Webb

American Journal of Hospital Pharmacy

|May 1, 1976

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Potassium Penicillin G stability is unaffected by Ascorbic Acid Injection. Incompatibilities are pH-dependent, not due to the ascorbate ion itself, suggesting clearer naming conventions for injections.

Area of Science:

Pharmaceutical Science
Drug Stability Studies
Analytical Chemistry

Background:

Potassium Penicillin G is a critical antibiotic.
Ascorbic Acid Injection is commonly used.
Potential interactions between these drugs require investigation.

Purpose of the Study:

To evaluate the stability of Potassium Penicillin G when combined with Ascorbic Acid Injection in 5% Dextrose Injection.
To determine the impact of sodium ascorbate on penicillin G concentration over time.

Main Methods:

Hydroxylamine colorimetric assay method.
Microbiological assay method.
Analysis of Potassium Penicillin G concentration over an eight-hour period.

Main Results:

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The stability of Potassium Penicillin G was not adversely affected by the presence of sodium ascorbate.
Observed incompatibilities are attributed to pH variations, not the ascorbate ion.
Penicillin G concentration remained stable in the admixture.

Conclusions:

Sodium ascorbate does not negatively impact Potassium Penicillin G stability.
pH is the primary factor in reported penicillin-ascorbate incompatibilities.
Clarifying nomenclature (Ascorbic Acid Injection vs. Sodium Ascorbate Injection) is recommended to reduce literature confusion.