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Updated: Aug 6, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

Prolapse of the mitral valve: clinical spectrum and coronary arterial distribution

E Glassman, I Kronzon

    Cardiology
    |January 1, 1977
    PubMed

    Insights

    Mitral valve prolapse is not linked to coronary artery variations. This study found normal coronary artery distribution in patients with posterior mitral leaflet prolapse, refuting previous theories.

    Area of Science:

    • Cardiology
    • Cardiac Anatomy

    Background:

    • Idiopathic prolapse of the posterior mitral leaflet is a condition affecting heart valve function.
    • Previous research suggested a potential link between mitral valve prolapse and specific coronary artery patterns, such as the absence of the left circumflex artery.

    Purpose of the Study:

    • To investigate the coronary arterial anatomy in patients with idiopathic prolapse of the posterior mitral leaflet.
    • To determine if there are significant differences in coronary artery dominance and the origin of the atrioventricular groove branch compared to a control group.

    Main Methods:

    • Retrospective review of coronary angiograms from 31 patients diagnosed with idiopathic prolapse of the posterior mitral leaflet.
    • Analysis of coronary artery dominance (right vs. left) and the origin of the posterior atrioventricular groove branch.
    • Comparison with a control group of 30 patients with similar angiographic analysis.

    Main Results:

    • The study found no significant difference in the frequency of dominant right or left coronary arteries, or the origin of the atrioventricular groove branch, between patients with mitral valve prolapse and the control group.
    • In all analyzed cases, the atrioventricular groove branch originated from the right coronary artery, the left circumflex artery, or both, and was never absent.
    • The findings do not support the hypothesis that mitral valve prolapse is associated with the absence of the left circumflex coronary artery.

    Conclusions:

    • The coronary arterial distribution in patients with idiopathic prolapse of the posterior mitral leaflet falls within the normal range of anatomical variation.
    • This study refutes the previously advanced theory linking mitral valve prolapse to the absence of the left circumflex coronary artery.
    • Coronary angiographic patterns in this patient group do not indicate a specific association with mitral valve prolapse.

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