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Isolation of Leukocytes from the Human Maternal-fetal Interface
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Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Correlation of peripheral white cell and bone marrow changes with folate levels in pregnancy and their clinical

S Varadi, D Abbott, A Elwis

    Journal of Clinical Pathology
    |January 1, 1966
    PubMed

    Two hundred and thirty-eight ;megaloblastic' pregnancies are reviewed. Bone-marrow aspiration was performed in every case. Serum folate estimations were strongly suggestive of folic acid deficiency in only 34% of cases. If, however, the red cell folate was determined as well, there was an almost complete agreement with the changes in the erythroblasts. It is suggested that hyper-segmentation of the neutrophils in association with a diminished red cell folate level is indicative of significant folic acid deficiency. This series possibly shows a slight but statistically insignificant increase of accidental haemorrhage. No effect on birth weight or incidence of stillbirth was demonstrable.

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