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Uptake of 5-hydroxytryptamine by isolated platelets in childhood schizophrenia and autism

D V Siva Sankar

    Neuropsychobiology
    |January 1, 1977
    PubMed

    Insights

    Childhood schizophrenia and infantile autism show platelet abnormalities affecting serotonin accumulation. This defect is linked to the platelets themselves, not the plasma.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Pediatrics

    Background:

    • Previous research suggested platelet abnormalities in serotonin accumulation in childhood schizophrenia and infantile autism.
    • These findings pointed towards a potential role for platelets in these neurodevelopmental disorders.

    Purpose of the Study:

    • To further validate and investigate the platelet abnormality in serotonin accumulation in infantile autism.
    • To determine if the observed defect resides within the platelets or the plasma.

    Main Methods:

    • The study involved analyzing serotonin accumulation in platelets from individuals with infantile autism.
    • Comparative analysis was performed to differentiate between platelet-associated and plasma-associated defects.

    Main Results:

    • The study confirmed a platelet abnormality in serotonin accumulation in infantile autism.
    • Evidence indicates the defect is intrinsic to the platelets, not attributable to plasma factors.

    Conclusions:

    • The findings strengthen the association between platelet dysfunction and infantile autism.
    • The serotonin transport defect in infantile autism is localized to the platelet itself.

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