[Experience with chemotherapy in peritoneal carcinosis]

Area of Science:

• Oncology
• Medical Research

Context:

• Metastatic peritoneal carcinosis presents a significant clinical challenge.
• Effective treatment options for widespread peritoneal carcinosis are limited.

Purpose:

• To evaluate the efficacy and tolerance of intravenous 5-fluorouracil (5-FU) combined with paclitaxel (Ptc) in patients with metastatic peritoneal carcinosis.

Summary:

• Eight patients with metastatic peritoneal carcinosis received intravenous 5-FU and Ptc (intravenously and intraperitoneally).
• The treatment demonstrated good tolerance, with side effects consistent with standard 5-FU and Ptc therapy.
• Significant therapeutic benefit was observed, with ascitic effusion disappearing or reducing by over 50% in most patients.
• The general condition of patients improved following treatment.

Impact:

• This combination therapy offers a promising approach for managing metastatic peritoneal carcinosis.
• The findings suggest a potential improvement in quality of life for patients with this condition.
• Further research may validate this treatment regimen for broader clinical application.