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[Changes in hydroxybutyrate dehydrogenase and lactate dehydrogenase ratio after urologic operations]
Acta Chirurgica Academiae Scientiarum Hungaricae
|January 1, 1977
Insights
A study found a link between ECG repolarization abnormalities and the alpha-HBDH/LDH ratio in urological surgery patients. This suggests elevated LDH may indicate myocardial ischemia, not infarction, especially in older patients post-surgery.
Area of Science:
- Cardiology
- Biochemistry
- Urological Surgery
Context:
- Assessing cardiac complications in patients undergoing urological surgery.
- Understanding the diagnostic utility of cardiac biomarkers post-intervention.
- Investigating myocardial injury markers in non-cardiac surgical settings.
Purpose:
- To investigate the correlation between electrocardiogram (ECG) repolarization abnormalities and the alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) to lactate dehydrogenase (LDH) ratio.
- To determine if elevated LDH levels in post-operative patients, particularly the elderly, signify myocardial infarction or myocardial ischemia.
- To establish the diagnostic value of ECG findings in identifying myocardial damage during or after urological procedures.
Summary:
- A statistically significant correlation was observed between ischemic repolarization disorders on ECG and alterations in the alpha-HBDH/LDH ratio in 58 patients undergoing urological surgery.
- Elevated levels of lactate dehydrogenase (LDH) iso-enzymes of myocardial origin can occur post-extensive surgery, especially in aged individuals, without evidence of myocardial infarction.
- Electrocardiogram (ECG) findings proved instrumental in confirming that such rises in LDH are indicative of myocardial ischemia.
Impact:
- Provides a potential non-invasive method for detecting myocardial ischemia in urological surgery patients using ECG and LDH ratio.
- Highlights the importance of monitoring cardiac status in elderly patients after extensive surgical interventions.
- Contributes to the understanding of cardiac biomarker behavior in the context of non-cardiac surgery, differentiating ischemia from infarction.
Abstract:
In 58 patients subjected to urological surgery a statistically significant correlation was found between the repolarization disorder of ischaemic origin on the ECG and the changes in the alpha-HBDH/LDH ratio. After extensive interventions and particularly in aged subjects, the level of the LDH iso-enzyme of myocardial origin may rise without myocardial infarction. The rise is due to myocardial ischaemia, as proved by the ECG.