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Mean cerebral transit time in demented and normal elderly persons.
Age and Ageing
|November 1, 1977
Summary
Mean cerebral transit time (MCTT) increased with age in elderly subjects. Despite this, MCTT did not differ between demented and non-demented individuals, suggesting cognitive status doesn't impact this specific blood flow measure.
Area of Science:
- Neurology
- Gerontology
- Medical Imaging
Background:
- Cerebral blood flow is crucial for cognitive function.
- Aging affects both cerebral circulation and cognitive health.
- Understanding circulation time in elderly populations is important for assessing brain health.
Purpose of the Study:
- To investigate the relationship between mean cerebral transit time (MCTT) and aging.
- To explore the correlation of MCTT with arm-to-head circulation time.
- To determine if MCTT differs between elderly individuals with and without chronic dementing illness.
Main Methods:
- Measurement of mean cerebral transit time (MCTT) in 31 elderly participants.
- Assessment of arm-to-head circulation time.
- Comparison of MCTT values between demented and non-demented patient groups.
Main Results:
- A significant positive correlation was found between MCTT and arm-to-head circulation time.
- Both MCTT and arm-to-head circulation time showed a significant increase with advancing age.
- No statistically significant difference in MCTT was observed between demented and non-demented subjects.
Conclusions:
- Cerebral circulation time, as measured by MCTT, is influenced by age.
- Arm-to-head circulation time is a relevant correlate of MCTT in the elderly.
- Chronic dementing illness in the elderly does not appear to significantly alter MCTT compared to non-demented individuals.