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Updated: Sep 4, 2026

Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice
Published on: March 10, 2017
Liver reaction to tissue injury: do therapeutic measures trigger the acute phase reaction?
Abstract:
In 30 healthy people we investigated the hypothesis that therapeutic measures trigger the acute phase reaction. In order of severity we analyzed: (1) the effects of an intramuscular injection of 2.5 ml 0.14 molar NaCl (6 patients), (2) the effects of an indwelling venous catheter for 24 h (7 patients), and for 72 h (8 patients), (3) the effects of cardiac catheterization (arterial and venous catheterization) carried out in 9 patients. In clinical investigations of the acute phase reaction, an intramuscular injection and a 24- or 72-h indwelling catheter, brought in by venipuncture, are acceptable because they do not provoke an acute phase reaction. A venous cutdown associated with an arterial puncture is not acceptable because this injury evokes a positive acute phase reaction. This was also observed in two patients who developed phlebitis during a 24-h indwelling venous catheter. Only a positive acute phase reaction was found, not a negative one.
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