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Related Experiment Videos

Photochemotherapy for psoriasis.

H H Roenigk, J S Martin

    Archives of Dermatology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Photochemotherapy using oral methoxsalen and ultraviolet A (UVA) light effectively treated severe psoriasis in 186 patients. Most achieved significant skin clearance with minimal side effects, requiring weekly maintenance treatments.

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    Area of Science:

    • Dermatology
    • Photobiology
    • Photomedicine

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • Severe psoriasis often requires intensive treatment options.
    • Photochemotherapy is a recognized treatment modality for psoriasis.

    Purpose of the Study:

    • To evaluate the efficacy and safety of oral methoxsalen combined with ultraviolet A (UVA) photochemotherapy for severe psoriasis.
    • To determine optimal UVA dosing and maintenance protocols.
    • To assess patient outcomes and side effects.

    Main Methods:

    • 186 patients with severe psoriasis were treated with oral methoxsalen and UVA phototherapy.
    • Various phototherapy units with high-output black lights were utilized.
    • Treatment involved initial clearing doses and subsequent weekly maintenance UVA doses.

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    Main Results:

    • Excellent or good clearance (80%-100%) was achieved in 77% of patients.
    • The average UVA dose for clearing ranged from 7 to 8 joules/sq cm.
    • Minimal side effects and abnormal laboratory findings were reported.

    Conclusions:

    • Oral methoxsalen and UVA photochemotherapy is a highly effective treatment for severe psoriasis.
    • Weekly maintenance UVA doses are generally sufficient to maintain remission.
    • The treatment demonstrates a favorable safety profile with minimal adverse events.