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Related Experiment Videos

Some morphological observations on osteoclasts.

S J Jones, A Boyde

    Cell and Tissue Research
    |December 19, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Scanning electron microscopy revealed osteoclasts possess complex, branching forms, differing from prior understandings. These motile cells, identified as non-resorbing, exhibit unique surface features and interactions with bone matrix.

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    Area of Science:

    • Cell Biology
    • Histology
    • Biomineralization

    Background:

    • Osteoclasts are crucial for bone resorption.
    • Previous studies have depicted osteoclasts with simpler morphologies.

    Purpose of the Study:

    • To investigate the detailed morphology of osteoclasts in young rat parietal and frontal bones.
    • To characterize the surface features and potential motility of osteoclasts using advanced microscopy.

    Main Methods:

    • Scanning electron microscopy (SEM) was employed.
    • Specimens were prepared using glutaraldehyde fixation and critical point drying.

    Main Results:

    • Osteoclasts exhibit complex, branching, and elongated forms, often elevated above the bone matrix.

    Related Experiment Videos

  • Motile, non-resorbing osteoclasts display microvilli and a distinct serrated border interacting with the matrix.
  • Osteoclasts in culture show additional surface ruffles not seen in vivo.
  • No evidence of osteoblast or osteocyte recruitment into osteoclasts was observed.

    • Conclusions:

    • Osteoclast morphology is more intricate than previously recognized.
    • Osteoclasts possess specialized surface structures for interaction with bone matrix.
    • Osteocytes demonstrate migratory capabilities from lacunae.