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[Methodological observations on double radionuclide technics in joint scintigraphy].

H Creutzig

    Nuklearmedizin. Nuclear Medicine
    |December 1, 1977
    PubMed
    Summary
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    This study evaluates radiopharmaceuticals for joint disease imaging. Technetium-99m labeled red blood cells are suitable intravascular tracers for differentiating inflammatory and degenerative joint diseases.

    Area of Science:

    • Nuclear medicine
    • Radiopharmacology
    • Medical imaging

    Background:

    • Differentiating inflammatory and degenerative joint diseases requires specific radiopharmaceuticals.
    • An ideal method uses an intravascular tracer for blood flow and an osteotropic agent.

    Purpose of the Study:

    • To evaluate radiopharmaceuticals for double-radionuclide scintigraphy in joint disease differentiation.
    • To identify suitable intravascular and osteotropic radiotracers.

    Main Methods:

    • Investigated 113mIn-labelled transferrin and 99mTc-labelled red cells as intravascular tracers.
    • Compared the behavior of 99mTc-labelled red cells with 51Cr-labelled red cells.
    • Considered 113mIn-EDTMP as an osteotropic radiopharmaceutical.

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    Main Results:

    • 113mIn-labelled transferrin does not remain intravascular during inflammatory disease.
    • 99mTc-labelled red cells behave like 51Cr-labelled red cells up to 30 minutes post-injection.
    • 99mTc-labelled red cells are suitable intravascular tracers in inflammatory conditions.

    Conclusions:

    • 99mTc-labelled red cells are appropriate intravascular tracers for joint disease scintigraphy.
    • 113mIn-EDTMP is a suitable osteotropic radiopharmaceutical for use with 99mTc-labelled red cells.