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Related Experiment Videos

Surface-modified acrylic polymers in artificial heart pumps.

Z Ott

    Polimery W Medycynie
    |January 1, 1977
    PubMed
    Summary

    Hydrophilization of poly(methyl methacrylate) (PMMA) blood pump surfaces reduced blood coagulation. Chemical treatments using ethylenglycol, diethylenglycol, or glycerine improved biocompatibility in canine models.

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    Area of Science:

    • Biomaterials Science
    • Cardiovascular Engineering
    • Surface Chemistry

    Background:

    • Poly(methyl methacrylate) (PMMA) is used in cardiovascular devices.
    • Surface interactions with blood can lead to coagulation, a critical issue in heart pump function.
    • Reducing surface thrombogenicity is essential for improving the safety and efficacy of blood-contacting medical devices.

    Purpose of the Study:

    • To investigate the effect of a hydrophilization process on the coagulation activity of PMMA surfaces.
    • To evaluate different chemical treatments for reducing the thrombogenicity of PMMA used in counterpulsation heart pump blood chambers.

    Main Methods:

    • PMMA blood chambers underwent hydrophilization using concentrated sulfuric acid and neutralization.
    • Three variants of chemical treatment were applied: ethylenglycol (A), diethylenglycol (B), and glycerine (C).
    • Experiments were conducted using 30 dogs, comparing treated PMMA pumps with untreated controls.

    Main Results:

    • The hydrophilization process was specifically designed to reduce the surface's coagulation activity.
    • Comparative analysis was performed between treated and untreated PMMA surfaces in a physiological setting.
    • The study utilized a canine model (30 dogs) to assess the in vivo performance and biocompatibility.

    Conclusions:

    • Hydrophilization of PMMA surfaces offers a promising strategy to mitigate blood coagulation.
    • The tested chemical treatments (ethylenglycol, diethylenglycol, glycerine) demonstrate potential for enhancing the biocompatibility of PMMA-based cardiovascular devices.
    • Further research into optimized surface modification techniques is warranted for improved hemocompatability in cardiac assist devices.

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