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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

[Extremly high frequency of infantil pulmonary thrombo-embolism (author's transl)]

K Brass

    Beitrage Zur Pathologie
    |November 1, 1977
    PubMed

    Insights

    Infant pulmonary thromboembolism was frequent in children under four years old, often linked to severe diarrheal diseases and dehydration. This study highlights a concerning trend in Valencia during 1951-1970.

    Area of Science:

    • Pediatric Pathology
    • Public Health
    • Epidemiology

    Context:

    • Autopsy data from 5,875 children (24 hours to 14 years) between 1951-1970 in Valencia.
    • Identified 115 cases of pulmonary thromboembolism, with 96 occurring in children under four years old.
    • Investigated the high incidence of infant pulmonary thromboembolism in a specific region and time period.

    Purpose:

    • To determine the frequency and potential causes of pulmonary thromboembolism in children.
    • To explore the association between severe diarrheal diseases, dehydration, and thrombosis.
    • To understand the influence of environmental and socioeconomic factors on pediatric health outcomes.

    Summary:

    • A high incidence of pulmonary thromboembolism was observed in young children, particularly those under four years old.
    • Thrombosis in renal veins and cranial sinuses, secondary to severe dehydrating enterocolitis, was a significant contributing factor.
    • Environmental, sanitary, and socioeconomic conditions in Valencia likely exacerbated the severity and frequency of these conditions.

    Impact:

    • Highlights a previously underreported issue of infant pulmonary thromboembolism linked to infectious diseases and environmental factors.
    • Suggests a need for improved public health interventions and sanitation, especially in vulnerable populations.
    • Provides valuable historical data for understanding pediatric thrombotic events and their determinants.

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