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Histocompatibility antigens in vertebral ankylosing hyperostosis
The Journal of Rheumatology
|January 1, 1977
Summary
Human leukocyte antigen (HLA) antigen frequencies were analyzed in patients with vertebral ankylosing hyperostosis. Findings indicate a decrease in A9 and A11 specificities, with no significant link found for B27 antigen and bone formation.
Area of Science:
- Immunogenetics
- Rheumatology
- Orthopedics
Background:
- Vertebral ankylosing hyperostosis (VAH) is a condition characterized by excessive bone formation in the spine.
- The role of Human Leukocyte Antigen (HLA) genes in VAH pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the association between specific HLA antigens and the occurrence of vertebral ankylosing hyperostosis.
- To determine if the B27 antigen is linked to the new bone formation characteristic of VAH.
Main Methods:
- HLA typing for A, B, and C antigens was performed on 50 white patients diagnosed with VAH.
- Antigen frequencies in patients were compared to control populations.
Main Results:
- A statistically significant decrease in the frequency of A9 and A11 HLA specificities was observed in VAH patients.
- The B27 antigen was present in only 6% of VAH patients, a frequency not significantly different from controls.
- No significant association was found between the B27 antigen and the extent of new bone formation in VAH.
Conclusions:
- The findings suggest a potential protective role for A9 and A11 HLA antigens in VAH.
- The B27 antigen does not appear to be a significant factor in the development of new bone formation in VAH.