Related Experiment Video

Updated: Oct 13, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

Stereochemical analysis of the elimination reaction catalyzed by D-amino-acid oxidase

Y F Cheung, C Walsh

    Biochemistry
    |June 1, 1976
    PubMed

    More Related Videos

    Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources12:47

    Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

    Published on: January 22, 2018

    Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine09:14

    Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

    Published on: February 16, 2018

    Related Concept Videos

    Oxidations of Aldehydes and Ketones to Carboxylic Acids01:15

    Oxidations of Aldehydes and Ketones to Carboxylic Acids

    Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
    Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
    Acid Halides to Amides: Aminolysis01:07

    Acid Halides to Amides: Aminolysis

    Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
    In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
    Amides to Carboxylic Acids: Hydrolysis01:28

    Amides to Carboxylic Acids: Hydrolysis

    Amides can undergo either acid-catalyzed hydrolysis or base-promoted hydrolysis through a typical nucleophilic acyl substitution. Each hydrolysis requires severe conditions.
    Acid-catalyzed hydrolysis:
    Hydrolysis of amides under acidic conditions yields carboxylic acids. Since the reaction occurs slowly, hydrolysis requires the conditions of heat.
    The mechanism begins with the protonation of the carbonyl oxygen by the acid catalyst. The protonation makes the amide carbonyl carbon more...
    Amines to Alkenes: Hofmann Elimination01:16

    Amines to Alkenes: Hofmann Elimination

    Alkenes can be obtained from amines via an E2 elimination. The amine is first converted into a good leaving group, such as a quaternary ammonium salt. This is accomplished by treating the amine with an excess of alkyl halide, which results in a halide salt. Next, the halide salt is transformed into a hydroxide salt that functions as a base to enable elimination.
    Under thermal conditions, the hydroxide can abstract a proton from the β carbon; this generates an alkene with the simultaneous...
    Amines to Alkenes: Cope Elimination01:14

    Amines to Alkenes: Cope Elimination

    Cope elimination reaction involves the conversion of tertiary amines to alkene using hydrogen peroxide under thermal conditions, as depicted in figure 1.
    Radical Formation: Elimination00:51

    Radical Formation: Elimination

    Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions with respect to...