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Diminished hormonal responses to exercise in trained rats.

H Galbo, E A Richter, J J Holst

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |December 1, 1977
    PubMed
    Summary

    Physical training in rats enhances glucose regulation during exercise, leading to a blunted hormonal response. Trained rats show increased adipose tissue sensitivity to catecholamines, reducing the need for hormonal shifts during exercise.

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    Area of Science:

    • Exercise Physiology
    • Metabolic Regulation
    • Endocrinology

    Background:

    • Physical training alters metabolic and hormonal responses to exercise.
    • Understanding these adaptations is crucial for exercise science and sports medicine.

    Purpose of the Study:

    • To investigate the effects of a 12-week physical training program on metabolic and hormonal responses to forced swimming in male rats.
    • To elucidate the role of glucose concentrations and adipose tissue sensitivity in trained rats during exercise.

    Main Methods:

    • Male rats underwent a 12-week training program or remained sedentary.
    • Rats were subjected to rest or 45- and 90-minute forced swims.
    • Measurements included liver and muscle glycogen, plasma glucose, insulin, glucagon, epinephrine, norepinephrine, free fatty acids, lactate, and alanine.

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    Main Results:

    • Trained rats exhibited higher resting liver and muscle glycogen and lower plasma insulin.
    • During exercise, trained rats maintained higher blood glucose, with attenuated increases in glucagon and decreases in insulin compared to controls.
    • Trained rats had lower plasma epinephrine and norepinephrine during exercise, higher free fatty acids, and lower lactate and alanine.

    Conclusions:

    • Physical training blunts the hormonal response to exercise in rats, partly due to elevated glucose levels.
    • Trained rats display increased adipose tissue sensitivity to catecholamines, allowing for lipolysis and glycogen depletion without significant hormonal changes.