[Immunocytogenesis and formation of antibodies in experimentally aged animals (author's transl)]

The authors use white rats with experimentally induced Progeria-like syndrome of Selye. The immunologic response following inoculation with the extracellular microbe-parasite D, pneumoniae and the intracellular parasite Br. abortus 19 is studied serologically, cellularly and biochemically. The experimentally aged rats show diminished and retarded plasmocyte reaction and weaker and slower agglutinine synthesis as compared with the controls. The immunochemical analysis of the serums of the experimentally aged rats reveals changes in the serum fractions and an affected ratio of albumin/globulin. The data suggest a disturbed adaptation and a reversal to an older ontogenic form of the aged organism.