Plasma apoprotein changes after selective inhibition of hepatic triglyceride lipase in rat

Selective inhibition of hepatic triglyceride lipase (HTGL) by specific antibodies in rats led to an altered VLDL apoprotein composition. Apoprotein analysis by isoelectric focusing revealed a new protein band in VLDL and an increase in apoprotein E (apo E) content. Apoproteins in LDL and HDL remained unchanged. Electronmicroscopy showed a significant increase in particle size of VLDL from 452 to 497 A with no significant changes in LDL and HDL diameters.